TY - JOUR ID - 12996 TI - A Cellular Automata Model of Tumor Growth Based on Cell Cycle JO - Journal of Advanced Mathematical Modeling JA - JAMM LA - en SN - 2251-8088 AU - Pourhasanzade, Fateme AU - Sabzpoushan, Seyed Hojjat AU - Alizadeh, Ali Mohammad AU - Chamani, Reyhaneh AU - Chamani, Reyhaneh AD - Department of Biomedical Engineering, Research Laboratory of Biomedical Signals and Sensors, Iran University of Sciences and Technology, Tehran, Iran AD - Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran AD - Radiation Oncology Department, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2016 PY - 2016 VL - 6 IS - 2 SP - 55 EP - 74 KW - Cell Cycle KW - Immune system KW - Tumor Growth KW - breast cancer KW - In vivo DO - 10.22055/jamm.2016.12996 N2 - Breast cancer is one of the major causes of death among women. Therefore, studying the morphology of cancer is necessary. Computer models and simulations may help scientists better understand this disease, and improve current treatments. In this paper, a model of breast cancer based on Cell Cycle is presented. Five states for each cell in a 2D square lattice is considered. The rules for updating the states of the model in the Moore neighborhood are stochastic. The results of our simulations are presented with/without considering immune system. The growth fraction and necrotic fraction are used as output parameters beside a 2-D graphical growth presentation. Moreover, we introduced a new in-vivo study to measure the output parameters by using Tetrazolium chloride. It can be observed that there is an acceptable compatibility between the experimental tests and simulation results. UR - https://jamm.scu.ac.ir/article_12996.html L1 - https://jamm.scu.ac.ir/article_12996_230cdcf9df1d56a2483e463b8cf7d69a.pdf ER -