نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه بیوالکتریک، دانشکده مهندسی فیزیک، دانشگاه علم و صنعت
2 مرکز تحقیقات بیولوژی سرطان، انستیتو سرطان ایران، دانشگاه علوم پزشکی تهران
3 بخش رادیوتراپی-انکولوژی، انستیتو سرطان ایران، دانشگاه علوم پزشکی تهران، تهران، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Breast cancer is one of the major causes of death among women. Therefore, studying the morphology of cancer is necessary. Computer models and simulations may help scientists better understand this disease, and improve current treatments. In this paper, a model of breast cancer based on Cell Cycle is presented. Five states for each cell in a 2D square lattice is considered. The rules for updating the states of the model in the Moore neighborhood are stochastic. The results of our simulations are presented with/without considering immune system. The growth fraction and necrotic fraction are used as output parameters beside a 2-D graphical growth presentation. Moreover, we introduced a new in-vivo study to measure the output parameters by using Tetrazolium chloride. It can be observed that there is an acceptable compatibility between the experimental tests and simulation results.
کلیدواژه‌ها [English]
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